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Pharmaceutical Sciences > Faculty and Staff > Faculty Publications

Faculty Publications

Schmidt, B. H., Burgin, A. B., Deweese, J. E., Osheroff, N., and Berger, J. M. A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature. 2010 May 19.

Akers, W. S., Oj, J. J., Oestreich, J. H., Ferraris, S., Wethington, M., and Steinhubl, S. R. Pharmacokinetics and pharmacodynamics of a bolus and infusion of cangrelor: A direct parenteral P2Y12 receptor antagonist. J Clin Pharmacol. 2010 Jan;50(1):27-35.

Phipps, S. D, and Brackbill, M. L. Relationship between assessment item format and item performance characteristics. Am J Pharm Educ. 2009 Dec 17; 73(8).

Koek, W., Mercer, S. L., Coop, A., and France, C. P. Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl (diethoxymethyl) phosphinic acid (CGP35348). J Pharmacol Exp Ther. 2009 Sep;330(3):876-83.

Deweese, J. E., Guengerich, F. P., Burgin, A. B., and Osheroff, N. Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry. 2009 Sep 29;48(38):8940-7.

Hassan, H. E., Mercer, S. L., Cunningham, C. W., Coop, A., and Eddington, N. D. Evaluation of the P-glycoprotein (Abcb1) affinity status of a series of morphine analogs: comparative study with meperidine analogs to identify opioids with minimal P-glycoprotein interactions. Int J Pharm. 2009 Jun 22;375(1-2):48-54.

Oestreich, J. H., Holt, J., Dunn, S. P., Smyth, S. S., Campbell, C. L., Charnigo, R., Akers, W. S., and Steinhubl, S. R. Considerable variability in platelet activity among patients with coronary artery disease in response to an increased maintenance dose of clopidogrel. Coron Artery Dis. 2009 May;20(3):207-13.

Deweese, J. E., Burch, A. M., Burgin, A. B., and Osheroff, N. Use of divalent metal ions in the DNA cleavage reaction of human type II topoisomerases. Biochemistry. 2009 Mar 10; 48(9):1862-9.

Deweese, J. E., and Osheroff, N. The DNA cleavage reaction of topoisomerase II: Wolf in sheep’s clothing. Nucleic Acids Res. 2009 Feb; 37(3):738-48.

Deweese, J. E., and Osheroff, N. Coordinating the two protomer active sites of human topoisomerase IIalpha: Nicks as topoisomerase II poisons. Biochemistry. 2009 Feb 24;48(7):1439-41.

Hendrickson, S. L., Hutcheson, H. B., Ruiz-Pesini, E., Poole, J. C., Lautenberger, J., Sezgin, E., Kingsley, L., Goedert, J. J., Vlahov, D., Donfield, S., Wallace, D. C., and O'Brien, S. J. Mitochondrial DNA haplogroups influence AIDS progression. AIDS. 2008 Nov 30;22(18):2429-39.

Steinhubl, S. R., Oj, J. J., Oestreich, J. H., Ferraris, S., Charnigo, R., and Akers, W. S. Transitioning patients from cangrelor to clopidogrel: Pharmacodynamic evidence of a competitive effect. Thromb Res. 2008;121(4):527-34.

Mercer, S. L., Shaikh, J., Traynor, J. R., Matsumoto, R. R., and Coop, A. Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands. Eur J Med Chem. 2008 Jun;43(6):1304-8.

Mercer, S. L., Cunningham, C. W., Eddington, N. D., and Coop, A. Opioids and efflux transporters. Part 3: P-glycoprotein substrate activity of 3-hydroxyl addition to meperidine analogs. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3638-40.

Hutcheson, H. B., Lautenberger, J. A., Nelson, G. W., Pontius, J. U., Kessing, B. D., Winkler, C. A., Smith, M. W., Johnson, R., Stephens, R., Phair, J., Goedert, J. J., Donfield, S., and O'Brien, S. J. Detecting AIDS restriction genes: from candidate genes to genome-wide association discovery. Vaccine. 2008 Jun 6;26(24):2951-65.

Cunningham, C. W., Mercer, S. L., Hassan, H. E., Traynor, J. R., Eddington, N.D., and Coop, A. Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs. J Med Chem. 2008 Apr 10;51(7):2316-20.

Deweese, J. E., Osheroff, M. A., and Osheroff, N. DNA topology and topoisomerases: Teaching a “knotty” subject. Biochem Mol Biol Educ. 2008; 37(1):2-10.

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