John Dominic Smith, J.D., Ph.D.

Associate Professor of Chemistry

john.smith@lipscomb.edu

B.A. Drew University, Chemistry
M.S. Vanderbilt University, Chemistry
J.D. Vanderbilt University Law School
Ph.D. Vanderbilt University, Synthetic and Computational Inorganic Chemistry

Teaching Assignments

Introduction to Chemistry
General Chemistry I, II
General Chemistry Lab I, II
Honors General Chemistry Lab I, II
Organic Chemistry Lab II
Inorganic Chemistry
Advanced Inorganic Chemistry
Society and the Law

Research Interests

The Smith research group currently focuses on biomimicry of metalloenzyme active centers for catalysis of small inert molecules.  Our primary inspiration at the moment is the metalloenzyme α-carbonic anhydrase, which catalyzes the conversion of carbon dioxide to bicarbonate anion at its Zn2+ active center.  It does this by lowering the heterolytic bond dissociation energy (HBDE) of water by, according to our calculations, on the order of 70%.

However, when catalyzing reactions in the laboratory, we have the freedom to ignore biological restraints.  We have used Density Functional Theory (DFT) methods to study the HBDE of water with biomimics of the α-carbonic anhydrase active center, and have found that HBDE decreases with increasing charge-to-size ratio.  We have studied a number of biomimics that reduce the HBDE of water dramatically more than the natural metalloenzyme active center.  These theoretical data can provide guidance in the design of actual catalysts that could, for example, convert carbon dioxide into a more useful molecule.

Recent Publications, Presentations, Awards

J. Dominic Smith. “Legends and the Fall: C.S. Lewis’s Philosophy of the Fall as Found in His Fictional Works,” presented in the C.S. Lewis session.  Christian Scholars Conference, Lipscomb University, Nashville, TN, June 2010.

J. Dominic Smith.  Convener, Finding Beauty in Science and Methematics session.  Christian Scholars Conference, Lipscomb University, Nashville, TN, June 2010.

J.A. Gault, D.B. Allison, J.D. Smith.  “A DFT Study of Energetics in First-Row d-Block α-Carbonic Anhydrase Active Center Biomimics.”  Poster presented at 1st Meeting of the Southeast Enzyme Conference, Atlanta, GA, April 2010.

J.A. Gault, D.B. Allison, J.D. Smith.  “DFT Study of First-row d-Block Biomimics of the Active Center of α-Carbonic Anhydrase.”  In preparation for submission to J. Biol. Inorg. Chem.

J. D. Smith. A Case Study of the Aufbau Principle and the Ground State Electron Configurations of the First Row d-Block Metals.  Submitted to J. Chem. Ed

D.B. Allison, J.A. Gault, J.D. Smith.  “Heterolytic Bond Dissociation Energies of Water in α-Carbonic Anhydrase Active Center Biomimics.”  Poster presented at the 119th Meeting of the Tennessee Academy of Sciences, Knoxville, TN, October 2009.  (First Place, Chemistry Division Poster Competition)

John Smith.  “Integration of Faith and Science.”  TV interview on Issues of Faith.  NewsChannel 5+. Nashville.  7 July 2009.  (On the Web in the Issues of Faith Archives at http://www.newschannel5.com/Global/story.asp?S=5373419)

J. Dominic Smith.  “The Sacred, the Secular, and the Scientific: How Classroom Teaching and Personal Worldview Inform and Influence One Another,” presented in the Science, Research, and the Christian University Classroom session.  Christian Scholars Conference, Lipscomb University, Nashville, TN, June 2009.

J. Dominic Smith.  Convener, Science as Narrative in the Undergraduate Faith Journey: The Service Experience session.  Christian Scholars Conference, Lipscomb University, Nashville, TN, June 2009.

J. Dominic Smith. “Computational Chemistry in the Chemistry Classroom.”  Invited presentation at the 60th Southeast Regional Meeting of the American Chemical Society, Nashville, TN, November 2008.

K.T. Quisenberry, J.D. Smith, M. Voehler, D.F. Stec, T.P. Hanusa, W.W. Brennessel.  Trimethylsilylated Allyl Complexes of Nickel.  The Stabilized Bis(π-allyl)nickel Complex [η3-1,3-(SiMe3)2C3H3]2Ni and its Mono(π-allyl)NiX (X=Br, I) Derivatives.  J. Am. Chem. Soc., 127, 4376-4387 (2005).

K.T. Quisenberry, R.E. White, J.D. Smith, T.P. Hanusa.  First Row Transition Metal Bis(trimethylsilylallyl) Complexes.  (Invited paper to Inorg. Synth., accepted.) 

J.D. Smith.  Note, Big Threats Come in Small Packages: How to Regulate Fine Particulate Matter under Current International Environmental Law.  Vand. J. Transnat’l L.  (Accepted, 2004.) 

J.D. Smith, K.T. Quisenberry, T.P. Hanusa, W.W. Brennessel.  Bis[1,3-bis(trimethylsilyl)allyl]cobalt(II), a Stable Electron-Deficient Allyl Complex.  Acta Cryst. C60, m507-m508 (2004).

C.N. Carlson, J.D. Smith, T.P. Hanusa, W.W. Brennessel, V.G. Young, Jr.  Homoleptic Allyl Complexes of Chromium with Trimethylsilylated Ligands.  Formation and Molecular Structure of {[1-(SiMe3)C3H4]2Cr}2, [(1,3-(SiMe3)2C3H3]2, and [(1,1´,3-(SiMe3)3C3H2]2Cr.  J. Organomet. Chem., 683, 191-199 (2003).

J.D. Smith, T.P. Hanusa, C.N. Carlson, V.G. Young, Jr., W.W. Brennessel  “Sterically Stabilized π-allyl Complexes of the First-Row Transition Metals.”  Presented at the 224th National Meeting of the American Chemical Society, Boston, MA, August 2002; paper INOR-076 in the New Developments in Metal Allyl Chemistry Symposium, presented by T.P. Hanusa.

J.D. Smith, T.P. Hanusa, V.G. Young, Jr.  Steric Stabilization of Homoleptic Bis(π-allyl) Complexes of Chromium (II) and Iron (II).  J. Am. Chem. Soc., 123, 6455-6456 (2001).

J.D. Smith, T.P. Hanusa.  Trends in the Structures and Energetics of the Group 14 Metallocenes (C5H5)2M (M=Si-Pb): A Density Functional Theory Study.  Organometallics, 20, 3056-3062 (2001).

J.D. Smith, T.P. Hanusa, V.G. Young, Jr.  “Extraordinary Stability of the Monomeric Bis(π-allyl) Complexes, [η3-(C3(SiMe3)2H3]2M (M=Cr, Fe, Ni).”  Presented at the 221st National Meeting of the American Chemical Society, San Diego, CA, April 2001; paper INOR-632, presented by T.P. Hanusa.

J.D. Smith, T.P. Hanusa.  “A Density Functional Theory Study of Group 14 Metallocenes.”    Poster presented at the 51st Southeast Regional Meeting of the American Chemical Society, Knoxville, TN, October 1999.

J.D. Smith.  How to Write a Lab Report and Make Your Teacher Extremely Happy.  Vanderbilt University Department of Chemistry, Nashville TN, 1998.  (Used as a teaching resource for General Chemistry Laboratory from 1998 to present.)